Research · Clinical Trials · Evidence
The research,
made readable.
Plain-language summaries of the published studies and clinical trials on psychedelic and ketamine therapy, with an honest read on how strong the evidence really is.
Research
Guides and study library
Start-here chapters on how these treatments work, plus a searchable library of study summaries.
Clinical Trials
Trials tracker
Active and completed trials around the world, with a filter for trials running in Canada.
Evidence
Evidence by condition
Depression, PTSD, chronic pain and more: what the research shows so far, and how confident we can be.
Start here
- 01What ketamine therapy isHow ketamine is used as a treatment, the different ways it's given, and how that differs from recreational use.
- 02How psychedelics and ketamine work in the brainWhat researchers think is happening, from receptors to brain networks, and what's still unknown.
- 03What the evidence saysAn honest overview of where the research is strong, where it's promising and where it's thin.
- 04Safety, side effects and who shouldn't take partKnown risks, common side effects and the medical and psychiatric screening used in clinical research.
- 05What a treatment actually involvesScreening, preparation, dosing sessions and integration, as described in clinical research protocols.
- 06Cost and coverage in CanadaWhat treatment typically costs and what public and private plans may cover.
- 07Legal status and access in CanadaHow ketamine, psilocybin and MDMA are regulated, and the legal routes to access that exist today.
- 08History and common mythsWhere psychedelic medicine came from, why research stopped and restarted, and the myths that still circulate.
Latest studies
Evidence by condition
Depression and treatment-resistant depression
Studies of ketamine, esketamine and psilocybin for major depression, including depression that hasn't responded to other treatments.
PTSD
Research on MDMA-assisted therapy, ketamine and psilocybin for post-traumatic stress disorder.
Chronic pain
Ketamine infusions and emerging psychedelic research for chronic and neuropathic pain.
Alcohol and substance use
Trials of psilocybin, ketamine and other compounds for alcohol use disorder and other addictions.
Anxiety and end-of-life distress
Research on psilocybin for anxiety and depression in people facing serious illness.
Suicidal thoughts
What the research shows about rapid-acting treatments like ketamine for suicidal ideation.