Molecules
Molecule guides
What each molecule is, how it's being studied, and how strong the evidence is, condition by condition.
Looking for quick answers? See myths vs evidence.
Ketamine
An anaesthetic now used to treat depression. How ketamine works, what it has been studied for, and how strong the evidence is.
Esketamine
The approved ketamine nasal spray for treatment-resistant depression. What phase 3 trials found, including those that missed, and evidence strength.
Psilocybin
The key compound in 'magic mushrooms', now in late-stage trials for depression. How it works, what it's been studied for, and how strong the evidence is.
MDMA
Studied alongside therapy for PTSD, then turned down by the FDA in 2024. What the trials found, what regulators questioned, and how strong the evidence is.
LSD
One of the first psychedelics studied in medicine, now in late-stage trials for anxiety. How LSD works and how strong the evidence is.
Ibogaine and iboga
A plant compound studied for opioid addiction and brain injury, with serious heart risks. What the research shows, and how weak the evidence still is.
DMT and ayahuasca
DMT is a short-acting psychedelic; ayahuasca is an Amazonian brew containing it. Early depression trials, drug-interaction risks and evidence strength.
5-MeO-DMT
A very short-acting psychedelic, now in phase 3 as a nasal spray and inhaled treatment for depression. What trials found and how strong the evidence is.
Mescaline
The long-acting psychedelic in peyote and San Pedro cactus. Modern lab studies, very limited clinical evidence, and conservation and cultural concerns.