Chapter 1

What ketamine therapy is


How ketamine is used as a treatment, the different ways it's given, and how that differs from recreational use.

In progressLast updated September 26, 2026

This chapter is being written. Every chapter is reviewed against the published research before it goes live.

What this chapter will cover

  • Ketamine’s history, from anaesthetic to psychiatric treatment
  • Routes: IV infusion, intramuscular, esketamine nasal spray (Spravato), oral and lozenges
  • Why dose, setting and support matter
  • How ketamine differs from classic psychedelics